TCR Alpha-Beta Depletion is an advanced technique used in haematopoietic stem cell transplantation (HSCT) to enhance the safety and efficacy of the procedure. T-cell receptors (TCRs) are proteins foun.....
TCR Alpha-Beta Depletion is an advanced technique used in haematopoietic stem cell transplantation (HSCT) to enhance the safety and efficacy of the procedure. T-cell receptors (TCRs) are proteins found on the surface of T cells, and the alpha-beta variant is the most common type. By selectively depleting T cells that express the alpha-beta TCR, this method aims to reduce the incidence of graft-versus-host disease (GVHD) while maintaining effective anti-infection and anti-tumour response responses. This technique enables the use of haploidentical, or half-match donors, increasing the pool of potential donors and making transplants more accessible.
