CD45RA Depletion is a specialised technique used in allogeneic hematopoietic stem cell transplantation and cell therapy. CD45RA is a marker found on naïve T cells, which have not yet encountered antig.....
CD45RA Depletion is a specialised technique used in allogeneic hematopoietic stem cell transplantation and cell therapy. CD45RA is a marker found on naïve T cells, which have not yet encountered antigens. Depleting these cells from donor grafts helps to reduce the risk of graft-versus-host disease (GVHD), a common complication where the donor's immune cells attack the recipient's tissues. This technique is beneficial for patients with high-risk leukaemia, aplastic anaemia, and inherited metabolic disorders. In the context of CAR-T cell therapy, CD45RA depletion can be employed to enhance the safety and efficacy of the treatment by minimising the risk of GVHD. It is also applied in virus-specific T-cell therapies to selectively expand memory T cells that can combat infections post-transplantation. A technical complex procedure, it requires sophisticated equipment and expertise, making it available only in specialized centers
